Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach

Gamma-Knife Radio Surgery in Brain Metastasis

Brain Metastasis (BM) is the most common type of intracranial malignancies in adult. Lung, breast cancer and melanoma are the malignancies which contribute up to 80% of BM [1]. Until recently, the median overall survival for patients with BM has been troubled, and in general the expected survival is at most 6 months after diagnosis [2]. However, owing to the advance of sensitive imaging modalit...

Hippocampal sparing approach in fractionated stereotactic brain VMAT radio therapy: A retrospective feasibility analysis

Volumetric Modulated Arc Therapy (VMAT) techniques for fractioned stereotactic brain radiotherapy (FSBRT) can achieve highly conformal dose distribution to intracranial lesions. However, they can potentially increase the dose to hippocampus (H) causing neurocognitive toxicity during the first four months after irradiation. The purpose of this study was to assess the feasibility of hippocampal-s...

A brain network response to sham surgery.

Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson's disease (PD), which has become a useful model for studying the neurobiology of placebo responses. In this issue of the JCI, Ko and colleagues identify a neural circuit associated with...

Dosimetric Evaluation and Optimization of Fractionated Stereotactic Radio-Surgery

Global Surgery Priorities: A Response to Recent Commentaries